Number 11-07: Hemodynamic changes caused by percutaneous tricuspid valve implantation
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Number 11-07: Hemodynamic changes caused by percutaneous tricuspid valve implantation

Case from: Sohrab Fratz, Andreas Eicken, Heiko Stern, John Hess

Institute: Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center at the Technical University Munich, Germany

Clinical history: A 5-year old girl with tricuspid valve dysplasia was referred to our center for management of her tricuspid valve regurgitation. At the age of three, the tricuspid regurgitation was treated by a modified Alfieri stich1 and de Vega anuloplasty2. Five months later, the reconstructed valve was replaced by a Perimount™ valve with an inner diameter of 20 mm. This valve is a porcine pericardial bioprosthesis mounted on a cobalt-chromium alloy stent frame. Initial postoperative echocardiography showed no tricuspid regurgitation. However, since then tricuspid regurgitation had increased by echocardiographic assessment.

CMR findings before treatment: Hemodynamic assessment by CMR depicted tricuspid regurgitation of 20%, a reduced cardiac index of 2.5 l/min/m², a large RVEDV, and a small LVEDV (Movie 1, Figure 1A and B, Tables 1 and 2). The patient was reffered to the cath lab for percutaneous tricuspid valve implantation.



 Movie 1: stack of axial slices for RV and LV volume analysis acquired during free breathing before treatment



Figure 1A and B: End-diastolic RV and LV endocardial tracing before treatment


Table 1: Results of RV and LV volume analysis at CMR before treatment (for normal values see reference 12)

EF [%] EDV [ml] ESV [ml] SV [ml] EDVI [ml/m²] ESVI [ml/m²]
RV 35 86 56 30 117 77
58 39 17 23 54 23

Table 2: Results of flow measurements at CMR before treatment 


net [ml] forward[ml] backward [ml]
MPA 24 24 0
Aorta 25 25 0
RPA 14 14 0
8 9 1

Invasive procedure /cath lab: A Melody™ transcatheter pulmonary valve was implanted percutaneously through the groin into the biological Perimount™ valve in tricuspid position (Movie 3 and 4). The Melody™ transcatheter pulmonary valve is a bovine jugular vein valve sutured into a CP Stent™ that is composed of a gold-brazed platinum/iridium wire.




Movie 3 - Right ventriculography before Melody™ transcatheter valve implantation


Movie 4 - Right ventriculography after Melody™transcatheter valve implantation


CMR findings after treatment:  The day after the intervention CMR showed significant relevant hemodynamic improvements. Tricuspid valve regurgitation decreased to 0%, cardiac index increased to 3.3 l/min/m², RVEDV decreased, and LVEDV increased (movie 5, figure 2, table 3 and 4).



Movie 5: stack of axial slices for RV and LV volume analysis acquired during free breathing after treatment



Figure 2:  Enddiastolic RV and LV endocardial tracing after treatment


Table 3: Results of RV and LV volume analysis at CMR after treatment (for normal values see reference 12)

EF [%] EDV [ml] ESV [ml] SV [ml] EDVI [ml/m²] ESVI [ml/m²]
RV 33 79 53 26 108 72
57 48 21 27 65 28

 Table 4: Results of flow measurements at CMR after treatment 


net [ml] forward[ml] backward [ml]
MPA 27 27 0
Aorta 26 26 0
RPA 17 17 0
11 11 0

Conclusion: Tricuspid valve dysplasia is unlike Ebstein´s disease a rare disease3-5. It is commonly responsible for severe tricuspid regurgitation and presents as a surgical challenge6-10. This is also illustrated by this case. Percutaneous valve implantation was only possible in this case because previously the patient had been treated by a bioprosthesis mounted on stent frame. The stent provided the secure landing zone for the percutaneous valve.


Perspective: CMR guided the treatment and demonstrated significant beneficial hemodynamic changes in this 5-year-old patient without the need of sedation, contrast agent or radiation. No other method can quantify tricuspid regurgitation and RVEDVI. Furthermore, CMR can quantify cardiac index non-invasively. Therefore CMR can and will be used for life long follow-up in this patient. Two specific points need to be mentioned regarding RV and LV volume analysis of children with congenital heart disease. First, at our center, we feel that axial slice orientation is superior to LV short axis orientation when serial follow-up EDV analysis is required clinically11. Secondly, this case demonstrats that the stack of cine slices required for volume analysis can be generated during free-breathing, as shown by others12. This case also highlights the possibilities of quantifing tricuspid regurgitation by combining careful quantification of pulmonary blood flow and accurate measurements of RV volumes using the equation TR = x10013.


  1. Maisano F, Schreuder JJ, Oppizzi M, Fiorani B, Fino C, Alfieri O. The double-orifice technique as a standardized approach to treat mitral regurgitation due to severe myxomatous disease: surgical technique. Eur J Cardiothorac Surg. 2000;17(3):201-5.
  2. Kanter KR, Doelling NR, Fyfe DA, Sharma S, Tam VK. De Vega tricuspid annuloplasty for tricuspid regurgitation in children. Ann Thorac Surg. 2001 Oct;72(4):1344-8.
  3. Sharland GK, Chita SK, Allan LD. Tricuspid valve dysplasia or displacement in intrauterine life. J Am Coll Cardiol. 1991;17:944-949.
  4. Nathan AT, Marino BS, Dominguez T, Tabbutt S, Nicolson S, Donaghue DD, Spray TL, Rychik J. Tricuspid valve dysplasia with severe tricuspid regurgitation: fetal pulmonary artery size predicts lung viability in the presence of small lung volumes.Fetal Diagn Ther. 2010;27(2):101-5.
  5. Yam MC, Ng PC, Fok TF. Isolated congenital tricuspid valve dysplasia: a rare condition mimicking persistent pulmonary hypertension of the newborn. J Paediatr Child Health. 1996;32(6):536-8.
  6. Butera G, Pomè G, Giamberti A, Frigiola A, Chessa M, Carminati M. Surgical treatment of tricuspid valve dysplasia in the neonatal period. Ital Heart J. 2003;4(3):211-3.
  7. Katogi T, Aeba R, Ito T, et al. Surgical management of isolated congenital tricuspid regurgitation. Ann Thorac Surg 1998; 66: 1571-4.
  8. Kumar N, Gallo R, Al-Halees Z, Al-Fadley F, Duran CM. Unstented semilunar homograft replacement of tricuspid valve in Ebstein’s malformation. Ann Thorac Surg 1995;59: 320-2.
  9. Pasque M, Williams WG, Coles JG, Trusler CA, Freedom RM. Tricuspid valve replacement in children. Ann Thorac Surg 1987; 44: 164-8.
  10. Reddy VM, McElhinney DB, Brook MM, Silverman NH, Stanger P, Hanley FL. Repair of congenital tricuspid valve abnormalities with artificial chordae tendineae. Ann Thorac Surg 1998; 66: 172-6.
  11. Fratz S, Schuhbaeck A, Buchner C, Busch R, Meierhofer C, Martinoff S, Hess J, Stern H. Comparison of accuracy of axial slices versus short-axis slices for measuring ventricular volumes by cardiac magnetic resonance in patients with corrected tetralogy of fallot. Am J Cardiol. 2009 Jun 15;103(12):1764-9.

  12. Buechel EV, Kaiser T, Jackson C, Schmitz A, Kellenberger CJ. Normal right- and left ventricular volumes and myocardial mass in children measured by steady state free precession cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2009 Jun 21;11:19.

  13. Cawley PJ, Maki JH, Otto CM. Cardiovascular magnetic resonance imaging for valvular heart disease: technique and validation. Circulation. 2009 Jan 27;119(3):468-78.


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Have your say:  What do you think?  Latest posts on this topic from the forum

Re: Number 11-07: Percutaneous TV implantation
Here is the link: ...
On: 09/13/2011 By: fratz Read more?

Re: Number 11-07: Percutaneous TV implantation
Hi,Yes it is a rare case.Howver, I just heard from the Berlin group that 3 cases similiar to this one have been accepted by JACC for publication. I do not have further details, let?s keep our...
On: 04/07/2011 By: fratz Read more?

Re: Number 11-07: Percutaneous TV implantation
Very interesting case and must be pretty rare in such a youngster to have the stented valve in the tricuspid position to use as an anchor point for the new valve. Lovely images and a great use of CMR to...
On: 04/07/2011 By: nartis Read more?

Re: Number 11-07: Percutaneous TV implantation
Thank you all for your comments and questions.I?ll try to adress them:James asked, if the procedure was a "first":We have implanted another valve in the tricuspid position.And a further one in an old-fashioned RA-RV-Fontan-conduit...
On: 04/04/2011 By: fratz Read more?

Re: Number 11-07: Percutaneous TV implantation
1. The EDVI and ESVI numbers are greater than the non indexed numbers. Please clarify.2. The tricuspid regurgitation fraction by CMR is in mild range (20%) however the Cath before Melody valve shows severe TR (movie 3). I...
On: 04/02/2011 By: vikasrathi Read more?

Re: Number 11-07: Percutaneous TV implantation
Wow... firstly, what a fantastic result and lovely pictures to show it. I am an adult cardiologist and never seen a percut TV replacement before. I would imagine that this must be incredibly challenging to do with that...
On: 04/01/2011 By: dan_sado Read more?

Re: Number 11-07: Percutaneous TV implantation
Excellent case. I had not heard of this procedure before. Is this a first?CMR really adds in its formal and non-invasive quantification of RV volumes and regurgitant fraction. ...
On: 04/01/2011 By: moon Read more?

Number 11-07: Percutaneous TV implantation
This case is now online. It created a bit of debate among the reviewers and we'll make the discussion available here in forum. ...
On: 04/01/2011 By: chiarabd Read more?

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